Geert Vanden Bossche posits that a mass vaccination regime targeting very specific viral structures during an ongoing pandemic amounts to a global gain of function experiment. Further, that the resulting variants could be able to affect the vaccinated even more than the unvaccinated as the infection may elicit an immune memory response that is ineffective and that can interfere with the working of the general non-memory immune system, the system that may be protecting the young.
ZDoggMD mixes some rebuttal with some rather immature ad hominem:
Edward Nirenberg gets more into the nitty gritty in: Addressing Geert Vanden Bossche’s Claims. Most relevant to any possible virus evolution is the question of to what extent the vaccines are “leaky”. Relevant to safety is if they compromise natural immunity.
Dr. Izzy Gerstenbluth discusses mass vaccination during a pandemic with his colleague, Dr. Ashley Duits:
For H1N1 one piece of evidence was missing evolution:
In 1977, H1N1 influenza A virus reappeared after a 20-year absence. Genetic analysis indicated that this strain was missing decades of nucleotide sequence evolution, suggesting an accidental release of a frozen laboratory strain into the general population.